Publicações sobre BMC

(Concentrado de medula óssea)

New: Sampson S, Botto-Van Bemden A, Aufiero D
Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease
The Physician and Sports Medicine. 2013 Sep
View abstract

New: Jae-Do Kim, Gun Woo Lee, Gu Hee Jung, Cheung Kue Kim, Taehun Kim, Jin Hyung Park, Seong Sook Cha, Young-Bin Yoo
Clinical Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in Degenerative Arthritis of the Knee
European journal of Orthopaedic Surgery and Traumatology. 2014 Jan
View abstract

New: Hauser RAOrlofsky A
Regenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series.
Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4
View abstract

Filardo G, Madry H, Jelic M, Roffi A, Cucchiarini M, Kon E.
Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.
Knee Surg Sports Traumatol Arthrosc. 2013 Jan 11.
View abstract

Nishimoto S, Kawai K, Tsumano T, Fukuda K, Fujiwara T, Kakibuchi M.
Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb.
J Plast Surg Hand Surg. 2013 Apr 26.
Abstract

Pascual-Garrido C, Rolón A, Makino A.
Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup.
Stem Cells Int. 2012;2012:953510. doi: 10.1155/2012/953510. Epub 2011 Dec 18.
PubMed Abstract

Duygulu F, Demirel M, Atalan G, Kaymaz FF, Kocabey Y, Dülgeroğlu TC, Candemir H.
Effects of intra-articular administration of autologous bone marrow aspirate on healing of full-thickness meniscal tear: an experimental study on sheep.
Acta Orthop Traumatol Turc. 2012;46(1):61-7.
PubMed Abstract

Veronesi F, Giavaresi G, Tchon M, Borsari V, Nicoli Aldini N, Fini M.
Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease.
Stem Cells Dev. 2012 Nov 16. PMID: 23030230
PubMed Abstract

Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy
Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
World J Orthop 2012 July 18; 3(7): 101-108
[Full Article]

Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
Knee Surg Sports Traumatol Arthrosc.
[Full Article]

Regenerative Cell Review articles

New: Hernigou P, Homma Y, Flouzat Lachaniette CH, Poignard A, Allain J, Chevallier N, Rouard H.
Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells.
Int Orthop. 2013 Jul 24.
[Pubmed Abstract]

Christian Hendrich, Engelmaier Franz, Gerhart Waertel, Rolf Krebs, and Marcus Jager.
Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients.
Orthop Rev (Pavia). 2009 October 10; 1(2): e32. Doi: 10.4081/or.2009.e32
PubMed Abstract

Hollander AP, Dickinson SC, Kafienah W
Stem cells and cartilage development: complexities of a simple tissue.
Stem Cells 2010, 28:1992-1996.
Publisher Full Text

Vinatier C, Bouffi C, Merceron C, Gordeladze J, Brondello JM, Jorgensen C, Weiss P, Guicheux J, Noel D
Cartilage tissue engineering: towards a biomaterial assisted mesenchymal stem cell therapy.
Curr Stem Cell Res Ther 2009, 4:318-329.
PubMed Abstract Publisher Full Text

Mahmoudifar N, Doran PM
Chondrogenesis and cartilage tissue engineering: the longer road to technology development.
Trends Biotechnol 2012, 30:166-176
PubMed Abstract

Andre F. Steinart, Lars Rackwitz, Fabian Gilbert, Ulrich Noth, Rocky S Tuan
Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives.
Stem Cells Translational Medicine 2012; 1:237-247
Publisher Abstract

Hass R, Kasper C, Bohm S, Jacobs R
Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC.
Cell Commun Signal 2011, 9:12
PubMed Abstract Pubmed Full Text

Caplan AI
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.
J Cell Physiol 2007, 213:341-347.
PubMed Abstract

Prockop DJ
Marrow stromal cells as stem cells for nonhematopoietic tissues.
Science 1997, 276:71-74.
PubMed Abstract

Romih, et al
The Vertibral Interbody Grafting Site’s Low Concentration in Osteogenic Progenitors can Greatly Benefit from Addition of Iliac Crest Bone Marrow”
European Spine Journal; 14:645-648; 2005
PubMed Abstract

Poole AR
Cartilage in health and disease. In Arthritis and Allied conditions: A Textbook of Rheumatology. 13th edition. Edited by Koopman WS. Baltimore
Lipincott Williams and Wilkins; 1997: 255-308

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR
Multilineage potential of adult human mesenchymal stem cells.
Science 1999,284:143-147.
Abstract

Wynn RF, Hart CA, Corradi-Perini C, O’Neill L, Evans CA, Wraith JE, Fairbairn LJ, Bellantuono I
A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow.
Blood 2004, 104:2643-2645.
PubMed Abstract


Osteoarthritis Review articles

New: Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy
Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus
World J Orthop 2012 July 18; 3(7): 101-108
[Full Article]

New: Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
Knee Surg Sports Traumatol Arthrosc.
[Full Article]

Goldring MB, Goldring SR
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis.
Ann N Y Acad Sci 2010, 1192:230-237.
PubMed Abstract

Buckwalter JA, Saltzman C, Brown T
The impact of osteoarthritis: implications of research.
Clin Orthop Relat Res 2004, (427 Suppl):S6-S15
PubMed Abstract

Koelling S, Miosge N
Stem cell therapy for cartilage regeneration in osteoarthritis.
Expert Opin Biol Ther 2009, 9:1399-1405.
PubMed Abstract

Charles J. Malemud and Victor M. Goldberg
Future Directions for Research and Treatments of Osteoarthritis
Frontiers in Bioscience 4, d762-771, October 15, 1999
PubMed Abstract

Chevalier X
Intraarticular treatments for osteoarthritis: new perspectives
Curr Drug Targets 2010, 11:546-560.
PubMed Abstract

Pawan K. Gupta, Anjan K. Das, Anoop Chullikana and Anish S. Majumdar 
Mesenchymal stem cells for cartilage repair in osteoarthritis.
Stem Cell Research & Therapy 2012, 3:25 doi: 10.1186/scrt116
PubMed Abstract

Chen FH, Tuan RS
Mesenchymal stem cells in arthritic diseases.
Arthritis Res Ther 2008, 10:223.
Publisher Full Text

Niemeyer P, Krause U, Kasten P, Kreuz PC, Henle P, Sudkam NP, Mehlhorn A
Mesenchymal stem-cell based HLA-independent cell therapy for tissue engineering of bone and cartilage.
Curr stem Cell Res Ther 2006, 1:21-27
PubMed Abstract

Singh A Jasvinder
Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold?
BMC Medicine 2012, 10:44
Publisher Full Text

Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H
Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees.
J Tissue Eng Regen Med 2007, 1:74-79.
PubMed Abstract

Nejadnik H, Hui JH, Feng Choong EP, Tai B-C, Lee EH
Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study.
Am J Sports Med 2010, 38:1110-1116.
PubMed Abstract

Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B
Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients.
Int J Rheum Dis 2011, 14:211-215.
PubMed Abstract

Mohsen Emadedin MD, Naser Aghdmani MD PhD, Leilar Taghiyar MSc, Roghayeh Fazeli MD, Reza Moghadasali MSc, et al
Intra-articular injection of Autologous Mesenchymal Stem Cells in Six patients with Knee Osteoarthritis
Arch Iran Med. 2012; 15(7): 422-428.
PubMed Abstract

Kasemkijwattana C, Hongeng S, Kesprayura S, Rungsinaporn V, Chaipinyo K, Chansiri K
Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two case report.
J Med Assoc Thai 2011, 94:395-400.
PubMed Abstract

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D
Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
Pain Physician 2008, 11:343-353.
PubMed Abstract

 

HIP

Pak J
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series
J Med Case Rep 2011, 5:296.
PubMed Abstract Publisher Full Text

Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M.
Treatment of osteonectrosis of the femoral head with implantation of autologous bone-marrow cells: A pilot study
J Bone Joint Surg Am. 2004 Jun; 86-A(6):1153-60.
Publisher Abstract

Kuroda R, Ishida K, Matsumoto T, Akisue T, Fujioka H, Mizuno K, Ohgushi H, Wakitani S, Kurosaka M
Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells.
Osteoarthr Cartil 2007, 15:226-231.
PubMed Abstract

Haleem AM, Singergy AAE, Sabry D, Atta HM, Rashed LA, Chu CR, El Shewy MT, Azzam A, Abdel Aziz MT
The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results.
Cartilage 2010, 1:253-261.
PubMed Abstract Publisher Full Text

 

BONE HEALING

New: Vulcano E, Murena L, Falvo DA, Baj A, Toniolo A, Cherubino P.
Bone marrow aspirate and bone allograft to treat acetabular bone defects in revision total hip arthroplasty: preliminary report.
Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2240-9.
[Pubmed Abstract]

Gessman J, Koller M, Godry H, Schildhaur T, Seyhold D, Department of General and Trauma Surgery and Department of Surgical Research, BG University Hospital
Regenerate Augmentation with bone marrow concentrate after traumatic bone loss.
Orthopedic Reviews 2012; volume 4:e14
PubMed Abstract Publisher Full Text

Ph. Hernigou, MD; A. Poignard, MD; F. Beaujean, MD; H. Rouard, MD.
Percutaneous Autologous Bone-Marrow Grafting for Nonunions: Influence of the Number and Concentration of Progenitor Cells.
The Journal of Bone and Joint Surgery. 2005; 87:1430-1437
PubMed Abstract

 

Limb Ischemia

Yuyama, et al
Therapeutic Angiogenesis for Patients with Limb Ischemia by Autologous Transplantation of Bone Marrow Cells: A Pilot Study and Randomized Controlled Study”
The Lancet; 360:427-435; 2002
PubMed Abstract

Animal model

New: R K W Smith
STEM CELL THERAPY FOR TENDINOPATHY: LESSONS FROM A LARGE ANIMAL MODEL
Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.42
[Full Article]

New: Renzi S, Riccò S, Dotti S, Sesso L, Grolli S, Cornali M, Carlin S, Patruno M, Cinotti S, Ferrari M.
Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report.
Res Vet Sci. 2013 Feb 16. pii: S0034-5288(13)00019-2. doi: 10.1016/j.rvsc.2013.01.017
PubMed Abstract

Mokbel AN, El Tookhy OS, Shamaa AA, Rashed LA, Sabry D, El Sayed AM.
Homing and reparative effect of intra-articular of autologous mesenchymal stem cells in osteoarthritis animal model.
BMC Musculoskelet Disord. 2011 Nov 15; 12:259.
PubMed Abstract Publisher Full Text

Sato M, Uchida K, Nakajima H, Miyazaki T, Guerrero AR, Watanabe S, Roberts S, Baba H.
Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis.
Arthritis Res Ther. 2012 Feb 7;14(1):R31
PubMed Abstract Publisher Full Text

Alfaqeh H, Norhamdan MY, Chua KH, Chen HC, Aminuddin BS, Ruszymah BH
Cell based therapy for osteoarthritis in a sheep model: gross and histological assessment.
Med J Malaysia 2008, 63(Suppl A):37-38.
PubMed Abstract

Grigolo B, Lisignoli G, Desando G, Cavallo C, Marconi E, Tschon M, Giavaresi G, Fini M, Giardino R, Facchini A
Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit.
Tissue Eng Part C Methods 2009, 15:647-658.
PubMed Abstract

Murphy JM, Fink DJ, Hunziker EB, Barry FP
Stem cell therapy in a caprine model of osteoarthritis.
Arthritis Rheum 2003, 48:3464-3474.
PubMed Abstract

Wang W, Li B, Yang J, Xin L, Li Y, Yin H, Qi Y, Jiang Y, Ouyang H, Gao C
The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs.
Biomaterials 2010, 31:8964-8973
PubMed Abstract

Mauro Krampera, Sarah Glennie, Julian Dyson, Diane Scott, Ruthline Laylor, Elizabeth Simpson, and Francesco Dazzi.
Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide.
Blood May 1, 2003 vol. 101 no. 9 3722-3729
PubMed Abstract

Connelly JT, Wilson CG, Levenston ME
Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs
Osteoarthr Cartil 2008, 16:1092-1100.
PubMed AbstractPublisher Full Text

Fortier LA, Potter HG, Rickey EJ, Schnabel LV, Foo LF, Chong LR, Stokol T, Cheetham J, Nixon AJ.
Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.
J Bone Joint Surg Am. 2010 Aug 18; 92(10):1927-37
PubMed Abstract

Bouffi C, Thomas O, Bony C, Giateau A, Venier-Julienne MC, Jorgensen C, Montero-Menei C, Noel D
The role of pharmacologically active microcarriers releasing TGF-beta3 in cartilage formation in vivo by mesenchymal stem cells.
Biomaterials 2010, 31:6485-6493.
PubMed Abstract

 

Mesenchymal Cells

Weiss S, Hennig T, Bock R, Steck E, Richter W
Impact of growth factors and PTHrP on early and lage chondrogenic differentiation of human mesenchymal stem cells.J Cell Physiol 2010, 223:84-93.
PubMed Abstract

Aggarwal S, Pittenger MF
Human mesenchymal stem cells modulate allogeneic immune cell responses.
Blood 2005, 105:1815-1822.
PubMed Abstract

 

Subcutaneous G-CSF for angiogenesis

Tohru Minamino, Haruhiro Toko, Kaoru Tateno, Toshio Nagai, Issei Komuro.
Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis?
The lancet, Volume 360, Issue 9350, Pages 2083-2084, 21 December 2002
Abstract

 

Bone Marrow in vitro (lab studies)

Barry F, Boynton RE, Liu B, Murphy JM
Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components.
Exp Cell Res 2001, 268:189-200.
PubMed Abstract

Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
Cell Tissue Res 2005, 320:269-276.

Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A, Lapidot T
Chemokine receptor CXCR4-dependent inernalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.
Nat Immunol 2005, 6:1038-1046
PubMed Abstract

Publicações sobre PRP

(Plasma rico em plaquetas)

New: V M Ibrahim, S L Groah, A Libin, I H Ljungberg, D Aufiero, K Patell, S Sampson
Use of platelet rich plasma for the treatment of bicipital tendinopathy in spinal cord injury: a pilot study 
Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.39 (Vancouver, 2012)
[View]

New: Allan K. Mishra, MD, Nebojsa V. Skrepnik, MD, PHD, Scott G. Edwards, MD, Grant L. Jones, MD, Steven Sampson, DO,
Platelet-Rich Plasma Significantly Improves Clinical Outcomes in Patients With Chronic Tennis Elbow: A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients
Am J Sports Med July 3, 2013
[View Abstract ]

New: Steven Sampson, DO
Use of Platelet Rich Plasma for the Treatment of Bicipital Tendinopathy in Spinal Cord Injury: A Pilot Study. International Scientific Tendinopathy
Symposium (ISTS). Vancouver, Canada. Sept 30, 2012
[View]

Steven Sampson, DO
Game-Changer: Ultrasound-guided needle procedures offer accurate, cost-effective, and often less painful treatment of musculoskeletal disorders
Imaging Economics, September 2011, Dollars & Sense.
[View]

Steven Sampson DO, Michael Meng DC, Adam Schulte OMS III, Drew Trainor MS/OMS III, Roberto Montenegro PhD, Danielle Aufiero MD
Management of Dupuytren Contracture With Ultrasound-Guided Lidocaine Injection and Needle Aponeurotomy Coupled With Osteopathic Manipulative Treatment
JAOA. February 2011, Vol 111, No 2.
[View]

Steven Sampson, Danielle Aufiero, Michael Meng, Anthony Bledin, Terry Gillette, Mona Zall
Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.
[View]

Steven E. Sampson DO, Marty Reed MD, Holly Silvers MPT, Michael Meng DC, Bert Mandelbaum MD.
Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
The American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online. Print Dec 2010.
[View]

Preparation of blood for PRP injection

Review Articles

NewJennifer Davis
Platelet-rich Plasma Therapy: What You Should Know.
www.ArthritisToday.org
[Full Article]

New: Michael Scarpone, DO; David Rabago, MD; Edward Snell, MD; Patrick DeMeo, MD; Kristine Ruppert, Dr PH; Perry Pritchard, PT, ATC; Gennie Arbogast, ATC; John Wilson, MD, MS; John F. Balzano, MD
Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study
Global Adv Health Med. ;0(ja):2-2
[View abstract]

New: Vora A, Borg-Stein J, Nguyen RT.
Regenerative injection therapy for osteoarthritis: fundamental concepts and evidence-based review
American Academy of Physical Medicine and Rehabilitation. PM R. 2012 May;4(5 Suppl):S104-9
[View abstract]

New: Kenneth Mautner, Gerard Malanga & Ricardo Colberg
Optimization of ingredients, procedures and rehabilitation for platelet-rich plasma
injections for chronic tendinopathy

Future Medicine, 2011
[Full Article]

New: J. Alsousou, A. Ali, K. Willett et al.
The role of platelet-rich plasma in tissue regeneration
Informa Healthcare May 30, 2012
[View abstract]

Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA
Platelet-Rich Plasma: A Milieu of Bioactive Factors 
Arthroscopy 2012 Jan 25.
[View Abstract]

Platelet-Rich Plasma: A Milieu of Bioactive Factors
Arthroscopy: The Journal of Arthroscopic and Related Surgery, 2012
[View Abstract]

Rosalyn T Nguyen MD, Joanne Borg-Stein MD, Kelly McInnis DO.
Applications of Platelet-Rich Plasma in Musculoskeletal and Sports Medicine: An Evidence-Based Approach
PM&R; 2011 Mar; 3(3): 226-250.
[Go to Article]

Kenneth S Lee, John J Wilson, David P Rabago, Geoffrey S Baer, Jon A Jacobson, Camilo G Borrero.
Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future?
AJR Am J Roentgenol. 2011 Mar;196(3):628-36.
[Download full article]

Sampson S, Gerhardt M, Mandelbaum B.
Platelet rich plasma injection grafts for musculoskeletal injuries: a review
Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74.
[Download full article]

Tate K MD, Crane D.
Platelet Rich Plasma Grafts in Musculoskeletal Medicine
Journal of Prolotherapy. 2010 May; 2(2): 371-376.
[Download full article]

Crane D, Everts P.
Platelet Rich Plasma (PRP) Matrix Grafts. Practical Pain Management 
2008:8 (1):11-26.
[Download full article]

Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA.
Platelet-rich plasma: current concepts and application in sports medicine
J Am Acad Orthop Surg. 2009 Oct;17(10):602-8.
[View abstract]

Sánchez M, Anitua E, Orive G, Mujika I, Andia I.
Platelet-rich therapies in the treatment of orthopaedic sport injuries
Sports Med. 2009;39(5):345-54.
[View abstract]

Molloy T, Wang Y, Murrell G. 2003.
The Roles of Growth Factors in Tendon and Ligament Healing
Sports Med. 33(5):381-394
[View abstract]

Back to top

Human Studies: Tendon/Ligament

 

New: Jason L. Dragoo, MD, Hillary J. Braun, BA, Jennah L. Durham, BA, Bethany A. Ridley, BA, Justin I. Odegaard, MD, Richard Luong, BVSc DACVP and Steven P. Arnoczky, DVM
Comparison of the Acute Inflammatory Response of Two Commercial Platelet-Rich Plasma Systems in Healthy Rabbit Tendons
Am J Sports Med. 2012 April 10.
[View abstract]

SHOULDER

New: V M Ibrahim, S L Groah, A Libin, I H Ljungberg, D Aufiero, K Patel, S Sampson
Use of Platelet Rich Plasma For The Treatment Of  Bicipital Tendinopathy In Spinal Cord Injury: A Pilot Study 
Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.39.
[View abstract]

New: Maureen Leahy
PRP May Be Effective Treatment for RCT
American Academy of Orthopaedic Surgeons. 2013 Annual Meeting News February 19 – 23, 2013.
[View]

New: Muto T, Kokubu T, Mifune Y, Sakata R, Nagura I, Nishimoto H, Harada Y, Nishida K, Kuroda R, Kurosaka M..
Platelet-rich plasma protects rotator cuff-derived cells from the deleterious effects of triamcinolone acetonide.
J Orthop Res. 2012 Dec 31. doi: 10.1002/jor.22301.
[View abstract]

New: Rha DW, Park GY, Kim YK, Kim MT, Lee SC.
Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial.
Clin Rehabil. 2012 Oct 3. [Epub ahead of print]
PMID: 23035005 [PubMed - as supplied by publisher]
[View abstract]

New: Moon YL, Ha SH, Lee YK, Park YK.
Comparative Studies of Platelet-Rich Plasma (PRP) and Prolotherapy for Proximal Biceps Tendinitis.
Clin Should Elbow. 2011 Dec;14(2):153-158
[View abstract]

New: Jo CH, Kim JE, Yoon KS, Shin S.
Platelet-Rich Plasma Stimulates Cell Proliferation and Enhances Matrix Gene Expression and Synthesis in Tenocytes From Human Rotator Cuff Tendons With Degenerative Tears.
Am J Sports Med. 2012 Feb 23.
[View abstract]

Nickolas Garbis MD, Anthony A. Romeo MD, Geoffrey Van Thiel MD, MBA, Neil Ghodadra MD, Matthew T. Provencher MD, Brian J. Cole MD, MBA, Nikhil Verma MD
Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Shoulder
Platelet-rich plasma (PRP) has recently been a topic of significant interest in the orthopedic community. In addition to the numerous basic science studies regarding the in vitro effects of PRP, there is more literature regarding the use of PRP in the clinical setting. PRP is …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 165-169.
[View abstract]

ELBOW

New: Allan K. Mishra, MD, Nebojsa V. Skrepnik, MD, Scott G. Edwards, MD, Grant L. Jones, MD, Steve Sampson, DO, Doug A. Vermillion, MD, Matthew L. Ramsey, MD, David Karli, Vail, Arthur C. Rettig, MD.
Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients with Chronic Tennis Elbow
The Orthobiologic Institute, March, 2013.
[View]

Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, Sayeed YA, Smith J
Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection
PM R 2011 Oct; 3(10):900-11.
[View Abstract]

Allan Mishra MD, Taco Gosens MD, PhD
Clinical Indications and Techniques for the Use of Platelet-Rich Plasma in the Elbow
Platelet-rich plasma (PRP) is an emerging biological treatment option in sports medicine. Its value is best established for elbow-related disorders, such as lateral epicondylar tendinopathy. This common condition typically resolves with simple treatment modalities, …
Operative Techniques in Sports Medicine, 2011
[View Abstract]

Finnoff JT, Fowler SP, Lai JK, Santrach PJ, Willis EA, Sayeed YA, Smith J.
Treatment of Chronic Tendinopathy with Ultrasound-Guided Needle Tenotomy and Platelet-Rich Plasma Injection
PM R. 2011 Aug 25. Epub ahead of print
[View Abstract]

Taco Gosens MD/PhD, Joost C Peerbooms MD, Wilbert van Laar, Brenda L den Oudsten PhD.
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-Year Follow-Up
Am J Sports Med; 2011 Mar.
[View Abstract]

Keith S Hechtman MD, John W Uribe MD, Angie Botto-Vandemen PhD, Gary M Kiebzak PhD
Platelet-rich Plasma Injection Reduces Pain in Patients With Recalcitrant Epicondylitis
Orthopedics, February 2011.
[Go to article]

Rabago D, Best TM, Zgierska AE, Zeisig E, Ryan M, Crane D
A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma.
Br J Sports Med; 2009 Jul;43(7):471-81
[Go to article]

Alsousou J, Thompson M, Hulley P, Noble A, Willett K
The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
J Bone Joint Surg Br; 2009 Aug;91(8):987-96
[Go to article]

Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA
Platelet-rich plasma: current concepts and application in sports medicine. 
J Am Acad Orthop Surg; 2009 Oct;17(10):602-8
[Go to article]

Peerbooms, J. C., Sluimer, J., Bruijn, D. J., Gosens, T.
Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
Am J Sports Med 38: 255-262
[View abstract]

Mishra A, Pavelko T.
Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
Am J Sports Med. 2006 Nov;34(11):1774-8.
[View abstract]

Edwards SG, Calandruccio JH.
Autologous blood injections for refractory lateral epicondylitis
Am J Hand Surg. 2003;28(2):272–8.
[View abstract]

KNEE

New: De Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ.
Platelet-Rich Plasma Added to the Patellar Tendon Harvest Site During Anterior Cruciate Ligament Reconstruction Enhanced Healing
Am J Sports Med. 2012 Jun;40(6):1282-8.
[Full Article]

New: Podesta L, Crow SA, Volkmer D, Bert T, Yocum LA.
Treatment of Partial Ulnar Collateral Ligament Tears in the Elbow With Platelet-Rich Plasma.
Am J Sports Med. 2013 May 10
[View Abstract]

New: Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J.
Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis.
Clin J Sport Med. 2012 Dec 12.
[View abstract]

Giuseppe Filardo, Elizaveta Kon, Stefano Della Villa, Ferruccio Vincentelli, Pier Maria Fornasari and Maurilio Marcacci
Use of platelet-rich plasma for the treatment of refractory jumper’s knee
International Orthopaedics; 31 July 2009; Vol 24, No 6; 909-915
[View Abstract]

Elizaveta Kon, Giuseppe Filardo, Marco Delcogliano, Mirco Lo Presti, Alessandro Russo, Alice Bondi, Alessandro Di Martino, Annarita Cenacchi, Pier Maria Fornasari, Maurilio Marcacci
Platelet-rich plasma: New clinical application: A pilot study for treatment of jumper’s knee
International Journal of the Care of the Injured; 2009 June; 40(6): 509-603
[View Abstract]

Kelly L. Scollon-Grieve, MD, Gerard A. Malanga, MD
Platelet-Rich Plasma Injection for Partial Patellar Tendon Tear in a High School Athlete: A Case Presentation
American Academy of Physical Medicine and Rehabilitation, Vol. 3, 391-395, April 2011.
[Full Article]

A knee injection under ultrasound guidance

FOOT/ANKLE

New: Monto, Raymond R MD
Platelet Rich Plasma and Plantar Fasciitis 
Sports Medicine and Arthroscopy Review. Dec 2013
View Abstract

New: Kumar V, Millar T, Murphy PN, Clough T.
The treatment of intractable plantar fasciitis with platelet-rich plasma injection.
Foot (Edinb). 2013 Jul 29.
[View]

New:Kim E, Lee JH.
Autologous Platelet-Rich Plasma Versus Dextrose Prolotherapy for the Treatment of Chronic Recalcitrant Plantar Fasciitis.
PM R. 2013 Jul 19.
[View]

New: Martinelli N, et al.
Platelet-rich plasma injections for chronic plantar fasciitis.
Int Orthop. 2012 Dec 19.
[View abstract]

New: Monto RR.
Platelet rich plasma treatment for chronic achilles tendinosis.
Foot Ankle Int. 2012 May;33(5):379-85.
[View abstract]

New: Ragab EM, Othman AM.
Platelets rich plasma for treatment of chronic plantar fasciitis.
Arch Orthop Trauma Surg. 2012 May 4
[View abstract]

New: Monto, R.
Platelet-Rich Rich Plasma is More Effective than Cortisone for Chronic Severe Plantar Fasciitis
2012  Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.
[View abstract]

Xiaofeng Jia MD, PhD, Paul G. Peters MD, Lew Schon MD
The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions
Platelet-rich plasma (PRP) contains growth factors derived from venous blood. Bone marrow concentrate (BMC) is an analogous platelet-rich product that is generated from bone marrow aspirate and might have the added advantage of containing mesenchymal stem cells. …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 177-184.
[View Abstract]

Steven Sampson, Danielle Aufiero, Michael Meng, Anthony Bledin, Terry Gillette, Mona Zall
Platelet-rich plasma therapy as a first-line treatment for severe Achilles tendon tear: a case report
International Journal of Therapy and Rehabilitation. February 2011, Vol 18, No 2.
[View]

Wiegerinck JI, Reilingh ML, de Jonge MC, van Dijk CN, Kerkhoffs GM
Injection Techniques of Platelet-Rich Plasma Into and Around the Achilles Tendon: A Cadaveric Study
Am J Sports Med, April 19 2011.
[View abstract]

Gaweda K.
Treatment of Achilles Tendinopathy with Platelet RichPlasma
International Journal of Sports Med, June 2010.
[View abstract]

P Robert J. de Vos et al.
Platelet-Rich Plasma Injection for Chronic Achilles Tendinopathy: A Randomized Controlled Study
JAMA 2010, 3003(2): 144-149.
[Full article]

Monto, R.
Platelet Rich Plasma (PRP) Effectively Treats Chronic Achilles Tendinosis
2010 Annual American Academy of Orthopaedic Surgeons meeting Podium Presentations.
[Read]

O’ Malley M.
Platelet-rich plasma (PRP) in managing Achilles tendinosis
2010 Annual American Orthopaedic Foot & Ankle Society (AOFAS) Meeting.
[Read]

Filardo, G, Lo Presti M, Kon E, Marcacci M. 2010.
Nonoperative Biological Treatment Approach for partial Achilles Tendon Lesion
Orthopedics 1;33(2):120-3.
[Full article]

Barrett S, Erredge S.
Growth factors for chronic plantar fasciitis
Podiatry Today 2004;17:37.
[Full article]

HAMSTRING

New: Hamid M, Ali M, Yusof A, George J.
Platelet-Rich Plasma (PRP): an adjuvant to hasten hamstring muscle recovery. A randomized controlled trial protocol (ISCRTN66528592)
BioMedCentral 2012
[Download full article]

 

 

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Human Studies: Muscle

New: Bernuzzi G, Petraglia F, Pedrini MF, De Filippo M, Pogliacomi F, Verdano MA, Costantino C.
Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection.
PM 2013 Jul 3
[View]

New: Borrione P, Grasso L, Chierto E, Geuna S, Racca S, Abbadessa G, Ronchi G, Faiola F, Di Gianfrancesco A, Pigozzi F.
Experimental model for the study of the effects of platelet-rich plasma on the early phases of muscle healing.
PM 2013 Jun 19
[View]

New: Gino Bernuzzi, Federica Petraglia, Martina Francesca Pedrini, Massimo De Filippo, Francesco Pogliacomi, Michele Arcangelo Verdano, Cosimo Costantino
Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection
Society on Transfusion Medicine and Immunohaematology (SIMTI) Published online: 03/07/2013
[View Abstract]

Hector A. Mejia MD, James P. Bradley MD
The Effects of Platelet-Rich Plasma on Muscle: Basic Science and Clinical Application
Muscle injuries are the most common type of injuries in sports. The natural course in this repair process is often slow, incomplete, and unpredictable. For competitive or professional athletes, this delay or unpredictability in complete healing may be costly or career ending. …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 149-153.
[View Abstract]

Hammond JW, Hinton RY, Curl LA, Muriel JM, Lovering RM
Use of autologous platelet-rich plasma to treat muscle strain injuries. 
Am J Sports Med; 2009 Jun;37(6):1135-42
[Go to article]

Nikolidakis D, Jansen JA
The biology of platelet-rich plasma and its application in oral surgery: literature review. 
Tissue Eng Part B Rev; 2008 Sep;14(3):249-58
[Go to article]

Borrione, Paolo MD; Gianfrancesco, Alessia Di PharmD; Pereira, Maria Teresa MD; Pigozzi, Fabio MD
Platelet-Rich Plasma in Muscle Healing
American Journal of Physical Medicine & Rehabilitation: October 2010 – Volume 89 – Issue 10 – pp 854-861.
[View abstract]

Mishra A, Woodall Jr. J, Vieira A. 2009.
Treatment of Tendon and Muscle Using Platelet-Rich Plasma
Clin Sports Med 28(1): 113-25.
[Download article]

Carpenter, T et al.
Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains
Int J Sports Med, 2004. 25:589-594.
[View abstract]

Hammond, JW et al.
Use of autologous platelet-rich plasma to treat muscle strain injuries 
American Journal of Sports Med, 2009. 37 (6): 1135-1142.
[Download article]

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Human Studies: Arthritis/Cartilage

KNEE

New: New: Alberto Gobbi, MD, Georgios Karnatzikos
The Use of Platelet-Rich Plasma in Degenerative Lesions of the Knee: Results at Two-year Follow Up
OASIS, Mar 20, 2013.
[View Abstract]

New: Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J.
Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis.
PMID: 23238250 [PubMed - as supplied by publisher]
[View abstract]

New: Sandeep Patel, Mandeep S. Dhillon, Sameer Aggarwal, Neelam Marwaha, and Ashish Jain
Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
AJSM PreView, published on January 8, 2013 as doi:10.1177/0363546512471299
[Full Article]

New: Ana Wang-Saegus, Ramón Cugat, Oscar Ares, Roberto Seijas, Xavier Cuscó, Montserrat Garcia-Balletbó
Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Arch Orthop Trauma Surg, Springer-Verlag 2010
[Full Article]

New: Antonio Frizziero · Erika Giannotti · Claudio Ferraro · Stefano Masiero
Platelet rich plasma intra-articular injections: a new therapeutic strategy for the treatment of knee osteoarthritis in sport rehabilitation.  A systematic review
Sport Sci Health (2012) 8:15–22
[Full Article]

New: Alberto Gobbi, MD, Georgios Karnatzikos, MD, Vivek Mahajan, MD, and Somanna Malchira, MD
Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
[Full Article]

New: Timea Spakova, PhD, Jan Rosocha, DVM, PhD, Marek Lacko, MD, Denisa Harvanova, PhD, Ahmed Gharaibeh, M
Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid
American Journal of Physical Medicine & Rehabilitation 0894-9115/12/9104-0000/0
[Full Article]

New: Napolitano M, Matera S, Bossio M, Crescibene A, Costabile E, Almolla J, Almolla H, Togo F, Giannuzzi C, Guido G
Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11. [Epub ahead of print]
[View Abstract]

Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M
Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis
Arthroscopy. 2011 Aug 8. (Epub ahead of print)
Biomechanics Laboratory-III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy.
[View Abstract]

Park SI, Lee HR, Kim S, Ahn MW, Do SH
Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures
Mol Cell Biochem. 2011 Sep 29. (Epub ahead of print)
Department of Orthopedic Surgery, College of Medicine, Yeungnam University, Daegu, 705-717, Korea.
[View Abstract]

Lisa A. Fortier DVM, PhD, Catherine H. Hackett DVM, PhD, Brian J. Cole MD, MBA
The Effects of Platelet-Rich Plasma on Cartilage: Basic Science and Clinical Application
Platelet-rich plasma (PRP) is emerging as a biological therapy for the treatment of cartilage injuries and for intra-articular application to address knee pain. Basic science studies indicate that PRP stimulates cell proliferation and the production of cartilage matrix by chondrocytes and …
Operative Techniques in Sports Medicine, Volume 19, Issue 3, September 2011, Pages 154-159.
[View Abstract]

Gerben M. van Buul, MD, Wendy L.M. Koevoet, BSc, Nicole Kops, BSc, P. Koen Bos, MD, PhD, Jan A.N. Verhaar, MD, PhD, Harrie Weinans, PhD, Monique R. Bernsen, PhD, Gerjo J.V.M. van Osch, PhD
Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes
The American Journal of Sports Medicine; August 19, 2011
[View Article]

Sampson, S.
Injection of Platelet-Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study
American Journal of Physical Medicine & Rehabilitation. Nov 20, 2010 online, Dec 2010 print. 961-969.
[View abstract]

Ana Wang-Saegusa, Ramón Cugat, Oscar Ares, Roberto Seijas, Xavier Cuscó and Montserrat Garcia-Balletbó.
Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Archives of Orthopaedic and Trauma Surgery, Volume 131, Number 3, 311-317, DOI: 10.1007/s00402-010-1167-3.
[View abstract]

Hunziker EB, Driesang IM, Morris EA. Clinical orthopaedics and related research.
Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
Clin Orthop Relat Res. 2001;391(Suppl):S171–81.
[View abstract]

Nakagawa K, Sasho T, Arai M, Kitahara S, Ogino S, Wada Y, et al.
Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes
Chiba and Ichihara, Japan. Electronic poster presentation P181. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.

Kon E, Filardo G, Presti ML, Delcogliano M, Iacono F, Montaperto C, et al.
Utilization of platelet-derived growth factors for the treatment of cartilage degenerative pathology
Bologna, Italy. Electronic poster presentation 29.3. International Cartilage Repair Society Meeting, Warsaw Poland, October 2007.

Anitua E, Sanchez M, Nurden AT, Zalduendo MM, De La Fuente M, Azofra J, et al.
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients
Rheumatology. 2007;46(12):1769–72.
[View abstract]

Kon E, Buda R, Mandelbaum B, Filardo G, Timoncini A, Delcogliano M, Fornasari P, Giannini S, Marcacci M.
PRP intra-articular injection versus viscosupplementation as treatments for early osteoarthritis
Podium Presentation, # 685. American Academy of Orthopaedic Surgeons, New Orleans LA. March 12, 2010.
[View]

Wu W, Zhang J, Dong Q, Liu Y, Mao T, Chen F
Platelet-rich plasma – A promising cell carrier for micro-invasive articular cartilage repair. [Journal Article, Research Support, Non-U.S. Gov't]
Med Hypotheses 2009 Apr; 72(4):455-7.
[View Abstract]

Sun, Y et al.
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
International Orthopaedics, 2010. 34:589-597.
[View abstract]

Elizaveta Kon, Roberto Bnda, Ginseppe Filardo, Alessandro Di Martino, Antonio Timoncini, Annarita Cenacchi, Pier Maria Fornasari, Sandro Giannini, Maurilio Marcacci.
Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions
Knee Surg Sports Traumatol Arthrosc. Sept 2009: 0940-8.
[Download full article]

Nathan Wei.
Tissue Engineering with Platelet-Rich Plasma and Stem Cells: New Frontier In Rheumatology
The Journal of Musculoskeletal Medicine. July 2009.
[Download full article]

Sanchez M, Azofra J, Anitua E, Andia I, Padilla S, Santisteban J, Mujika I (2003).
Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
Med Sci Sports Exerc 35:1648-1652.
[Download full article]

Berghoff W, Pietrzak W, Rhodes R.
Platelet-rich plasma application during closure following total knee arthroplasty
Orthopedics. 2006;29(7):590–8.
[Full article]

Gardner MJ, Demetrakopoulos D, Klepchick P, Mooar P.
The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty: an analysis of the haemoglobin, narcotic requirement and range of motion
Int Orthop. 2006;31:309–13.
[View abstract]

Everts P, Devilee R, Mahoney C, Eeftinck-Schattenenkerk M, Knape J, Van Zundert A.
Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty
Acta Anaesthesiol Scand. 2006;50:593–9.
[View abstract]

New: Sanchez M., Fiz N., Azofra J., Usabiaga J., Aduriz Recalde E., Garcia Gutierrez A., Albillos J., (…), Anitua E.
A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis
(2012) Arthroscopy – Journal of Arthroscopic and Related Surgery, 28 (8), pp. 1070-1078.
[View abstract]

HIP

New: Wetzel RJ, Patel RM, Terry MA.
Platelet-rich Plasma as an Effective Treatment for Proximal Hamstring Injuries.
Orthopedics. 2013 Jan 1;36(1):e64-70. doi: 10.3928/01477447-20121217-20.
[View abstract]

New: Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon
Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.
Knee Surg Sports Traumatol Arthrosc.
[Full Article]

New: Mikel Sánchez, Jorge Guadilla, Nicolás Fiz, Isabel Andia
Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip
Rheumatology (2011) doi: 10.1093/rheumatology/ker303 First published online: November 10, 2011.
[View abstract]

GENERAL

New: Alberto Gobbi, MD, Georgios Karnatzikos, MD, Vivek Mahajan, MD, and Somanna Malchira, MD
Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients 
Sports Health: A Multidisciplinary Approach 2012 4: 162 originally published online 20 January 2012
[Full Article]

New: Tımea Spakova, PhD, Jan Rosocha, DVM, PhD, Marek Lacko, MD, Denisa Harvanova, PhD, Ahmed Gharaibeh, M
Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid 
American Journal of Physical Medicine & Rehabilitation 0894-9115/12/9104-0000/0
[Full Article]

New: Napolitano M, Matera S, Bossio M, Crescibene A, Costabile E, Almolla J, Almolla H, Togo F, Giannuzzi C, Guido G
Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
Blood Transfus. 2011 Oct 25:1-6. doi: 10.2450/2011.0026-11. [Epub ahead of print]
[View abstract]

Human Studies: Nerve

NewM. Sánchez, T. Yoshioka, M. Ortega, D. Delgado, E. Anitua
Ultrasound-guided platelet-rich plasma injections for the treatment of common peroneal nerve palsy associated with multiple ligament injuries of the knee
Knee Surgery, Sports Traumatology, Arthroscopy Online ISSN 1433-7347
[View]

New: Doss AX
Trigeminal Neuralgia Treatment: A Case Report on Short-Term Follow up After Ultrasound Guided Autologous Platelet Rich Plasma Injections.
WebmedCentral NEUROLOGY 2012;3(5):WMC003381
[View]

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Animal Studies

New: Shuji Obata, Koji Akeda, Takao Imanishi, Koichi Masuda, Won Bae, Ryo Morimoto, Yumiko Asanuma, Yuichi Kasai, Atsumasa Uchida, Akihiro Sudo.
Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study
Arthritis Research & Therapy 2012, 14:R241
[Full article]

Kwon DR, Park GY, Lee SU.
The effects of intra-articular platelet-rich plasma injection according to the severity of collagenase-induced knee osteoarthritis in a rabbit model.
Ann Rehabil Med. 2012 Aug;36(4):458-65. Epub 2012 Aug 27.
PMID: 22977770 [PubMed]
[Read Abstract]

Geng Z, Wang C, Zhou H
Effect of platelet-rich plasma on tendon healing
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. Mar 2011; 25(3):344-8.
[View abstract]

Harris, N. Lindsay, MD; Purnell, Mark L., MD; Huffer, William E., MD; Larson, Andrew I.
The Effect of Platelet-Rich Plasma (PRP) on Normal Soft Tissues in the Rabbit BSME
Phinney, Shawn, MA; Von Stade, Eleanor F., MD. Aspen Orthopaedics Associates and Aspen Sports Medicine Foundation (AMSF).
[Download full article]

Wu W, Chen F, Liu Y, Ma Q, Mao T
Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. [Journal Article, Research Support, Non-U.S. Gov't]
J Oral Maxillofac Surg 2007 Oct; 65(10):1951-7.
[View Abstract]

Bir SC, Esaki J, Marui A, Yamahara K, Tsubota H, Ikeda T, Sakata R
Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse. [Comparative Study, In Vitro, Journal Article]
J Vasc Surg 2009 Oct; 50(4):870-879.e2.
[View Abstract]

Aspenberg P, Virchenko O. 2004.
Platelet concentrate injection improves Achilles tendon repair in rats
Acta Orthop Scand 75(1):93-9.
[Download article]

Taylor M, Norman T, Clovis N, Blaha D.
The response of rabbit patellar tendons after autologous blood injection
Med Sci Sports Exerc. 2002;34(1):70–3.
[View abstract]

Carpenter, T, et al.
Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model
Int J Sports Med, 2004. 25:1-6.
[Download article]

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Human Studies: Spine

New: Hu X, Wang C, Rui Y.
An experimental study on effect of autologous platelet-rich plasma on treatment of early intervertebral disc degeneration.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Aug;26(8):977-83. Chinese.
PMID: 23012935 [PubMed - in process]
[Related citations]

New: Schroeder, Josh; Grad, Sibylle; Verrier, Sophie; Peroglio, Marianna; Kaplan, Leon; Hasharoni, Amir; Barzilay, Yair; Liebergall, Meir; Richards, Geoff; Alini, Mauro
Proliferation of Annulus Fibrosus Cells in Platelet Rich Plasma ‐ A Natural 3D Scaffold: An in Vitro Study: Gp8
Spine: Affiliated Society Meeting Abstracts . Supplement 1:page #], October 2011.
[View abstract]

Adam D. Weglein
Focused Review: Current Trends in Platelet-Rich Plasma Injection Treatments
Journal of Neurosurgical Review, Vol 1 (2011).
[Download full article]

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PRP Physiology

Eppley BL, Woodell JE, Higgins J
Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
Plast Reconstr Surg. 2004 Nov;114(6):1502-8.
[View abstract]

Wang P, Qu Y, Man Y
Platelet-rich plasma as a scaffold for injectable soft-tissue augmentation. [JOURNAL ARTICLE]
Cytotherapy 2010 May 21.
[View Abstract]

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Rehabilitation post PRP

Van Ark M, Van den Akker-Scheek I, Meijer LT, Zwerver J.
An exercise-based physical therapy program for patients with patellar tendinopathy after platelet-rich plasma injection.
Phys Ther Sport. 2012 Sep 22
PMID: 23010772 [PubMed - as supplied by publisher]
[Read Abstract]